evaluation of three rubella vaccines in conferring protection

the effeminacy of three rubella vaccines, hpv/77 ide-5, cendehill-51 and wistar ra/27/3 in conferring immunity against untenanted rubella virus was compared. vaccination resulted in 90-100 percent protection against clinical rubella. intranasal challenge with the untenanted strain of rubella virus resulted in serologic evidence of in apparent reinfection in three of the ten cendehill-51 vaccines the virus was isolated from the throat specimens of two, and one developed adenopathy. two of the eleven ra/27/3 vaccines became reinfected. virus was isolated from the throat specimen of one and a booster response occurred in that other; the latter developed rash. all of the hpv/177/de-5 vaccines remained symptom less after the challenge. none demonstrated booster response and shed virus.